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REVIS is an international multi-disciplinary project that integrates knowledge from neurology, neuropsychology, neurophysiology, neuroimaging, informatics and medical engineering. It was implemented in Germany, Institute of the medicine psychology of Otto-von-Guericke University directed by Prof. Sabel, as well as in Poland, Italy and Finland. The aim of the project is to research and develop a new strategy for the treatment and rehabilitation of visual dysfunctions in patients with ischemic stroke.

This project builds on the “residual vision activation theory” and is designed to better understand residual visual functions and neuroplasticity changes in the chronic stage after posterior brain infarct. Specifically, the researchers identify mechanisms of local and global plasticity in chronic stroke patients. Local changes likely involve lateral interactions and receptive field adaptations in the tissue near or inside the scotoma; i.e. in the penumbra of the lesion or deep inside the scotoma. Global plasticity, on the other hand, implies changes in long-distance interactions which could be revealed by functional connectivity and current stimulation studies. They likely involve intra-hemispheric or interhemispheric long-range projections. These may inhibit the damaged region from the mirror-symmetric, intact cortex of the opposite hemisphere. The researches specifically studied if the post-lesion plasticity is adaptive (or maladaptive) by trying to alter the plasticity by the novel method of non-invasive transcranial and transorbital brain current stimulation using alternating (ACS) and direct current (DCS) stimulation protocols. These stimulation paradigms are designed to activate residual structures or suppress long-range inhibitory influences that are expected to lead to long-lasting vision restoration.

Key publications

Gall, C., Schmidt, S., Schittkowski, M.P., Antal, A., Ambrus, G.G., Paulus, W., Dannhauer, M., Michalik, R., Mante, A., Bola, M., Lux, A., Kropf, S., Brandt, S.A., Sabel, B.A. (2016) Alternating current stimulation for vision restoration after optic nerve damage: a randomized clinical trial. PLoS One, in press

Gall et al. (2015). Non-invasive electric current stimulation for restoration of vision after unilateral occipital stroke

Sergeeva, E.G., Henrich-Noack, P., Gorkin, A.G., Sabel, B.A. (2015) Preclinical model of transcorneal alternating current stimulation in freely moving rats. Restorative Neurology and Neuroscience 33: 761-769

Bola, M., Sabel, B.A. (2015) Dynamic reorganization of brain functional networks during cognition. Neuroimage 114: 398-413

Bola, M., Gall, C., Sabel, B.A. (2015) Disturbed temporal dynamics of brain synchronization in vision loss. Cortex 67: 134-146

Sergeeva, E.G., Bola, M., Wagner, S., Lazik, S., Voigt, N., Mawrin, C., Gorkin, A.G., Waleszczyk, W.J., Sabel, B.A., Henrich-Noack, P. (2015) Repetitive transcorneal alternating current stimulation reduces brain idling state after long-term vision loss. Brain Stimulation 8(6): 1065-1073

Gall, C., Silvennoinen, K., Granata, G., de Rossi, F., Vecchio, F., Brösel, D., Bola, M., Sailer, M., Waleszczyk, W.J., Rossini, P.M., Tatlisumak, T., Sabel, B.A. (2015) Non-invasive electric current stimulation for restoration of vision after unilateral occipital stroke. Contemporary Clinical Trials 43: 231-236

Sabel, B. (2015) Sind Gesichtsfeld-Defekte noch reversible? Wechselstrom zur Re-Synchronisation von Hirnnetzwerken verbessert Gesichtsfeld-Defekte: Update nach 110 Jahren. Ophthalmologische Nachrichten 07: 14-15

Dundon, N.M., Bertini, C., Làdavas, E., Sabel, B.A., Gall, C. (2015) Visual rehabilitation: visual scanning, multisensory stimulation and vision restoration trainings. Frontiers in Behavioral Neuroscience 9: 192

Abd Hamid, A.I., Gall, C., Speck, O., Antal, A., Sabel, B.A. (2015) Effects of alternating current stimulation on the healthy and diseased brain. Frontiers in Neuroscience 9: 391.

Bola et al. (2014) Brain functional connectivity network breakdown and restoration in blindness.

Conell, N. and Lotfi, B.M. (2014) Uncovering the connectivity of the brain in relation to novel vision rehabilitation strategies.

Foik et al. (2014). Retinal Origin of Electrically Evoked Potentials in Response to Transcorneal Alternating Current Stimulation in the Rat.